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Coming Special Issue for CURRENT Neuropharmacology

 Guest Editor: István Bókkon

Redox age: Functional roles of free radicals in neural processes

Aims & Scope:

Recent findings have provided evidence that ROS (reactive oxygen species) and RNS (reactive nitrogen species) and their derivatives act as essential signals in biological systems. Reactive species have been identified as regulated second messengers in cells, which play fundamental roles in cell receptor signaling and post-translation modification of signaling molecules, as well as in gene expression, apoptosis, cell growth, enzymatic functions, Ca²⁺ and redox homeostasis, and in numerous other processes. ROS, RNS and their derivatives also act as signaling molecules in cerebral circulation and are indispensable in molecular signal processes, synaptic plasticity, and memory formation under physiological circumstances. The aim of this issue is to review the possible functional roles of reactive species in neural signal processing, the putative role of free radical dysregulation in neurological diseases such as schizophrenia, Alzheimer`s disease, etc. Authors should write at least a section about possible relationships between their redox related thoughts and the neuropharmacology.